Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On November 23, 2009, Patrick Brady resigned from the Board of Directors of OncoGenex Pharmaceuticals, Inc.

Item 8.01 Other Events.

Following Mr. Brady's resignation, the Board of Directors appointed Neil Clendeninn to fill the vacancy thereby created on the Audit Committee and appointed Michelle Burris to fill the vacancy thereby created on the Nominating and Governance Committee and to serve as that committee's chair. The Board of Directors also fixed the size of the Board of Directors at five directors.

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