On November 4, 2009, OraSure Technologies, Inc. (the "Company") held a webcast conference call with analysts and investors, during which Douglas A. Michels, the Company's President and Chief Executive Officer, and Ronald H. Spair, the Company's Chief Financial Officer and Chief Operating Officer, discussed the Company's financial results for the quarter ended September 30, 2009, described certain business developments and provided financial guidance for the fourth quarter 2009. A copy of the prepared remarks of Messrs. Michels and Spair is attached as Exhibit 99 to this Form 8-K and is incorporated herein by reference.

(d) Exhibits

Exhibit
Number                                     Description

99            Prepared Remarks of Douglas A. Michels and Ronald H. Spair for
              OraSure Technologies, Inc. Third Quarter 2009 Analyst/Investor
              Conference Call Held November 4, 2009.