Item 2.02. RESULTS OF OPERATIONS AND FINANCIAL CONDITION

On October 27, 2009, MidSouth Bancorp, Inc. (the "Company") issued a press release regarding the Company's earnings for the quarter ended September 30, 2009. The Company's earnings release, including financial highlights, is attached as Exhibit 99.1.

The preceding information is being furnished pursuant to Item 2.02 of this Form 8-K. This information shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, except as shall be expressly set forth by specific reference in such filing.

Item 5.02. DEPARTURE OF DIRECTORS OR CERTAIN OFFICERS; ELECTION OF DIRECTORS; APPOINTMENT OF CERTAIN OFFICERS; COMPENSATORY ARRANGEMENTS OF CERTAIN OFFICERS

Karen L. Hail, Senior Executive Vice President and Chief Operating Officer of the Company, has requested a leave of absence under the Family and Medical Leave Act from the Company and its subsidiary, MidSouth Bank, N.A., effective October 23, 2009.

It is currently expected that Ms. Hail's leave of absence will continue through December 31, 2009. During her leave of absence, Ms. Hail's responsibilities will be assumed by other members of the Company's and the bank's senior management team.