Item 5.05 Amendments to the Registrant's Code of Ethics, or Waiver of a Provision of the Code of Ethics.

On October 15, 2009, the Board of Directors of Hemispherx Biopharma, Inc. (the "Company"), upon the recommendation of the Audit Committee of the Board of Directors, approved amendments to the Company's Code of Ethics.

The principal amendments include broadening the Code's application to agents and consultants of the Company, the adoption of a regulatory compliance policy and the adoption of a policy for protection and use of Company computer technology for business purposes only. The amendments to the Code of Ethics are effective immediately. None of the amendments constituted a waiver of a provision of the Code of Ethics on behalf of the Company's Chief Executive Officer, Chief Financial Officer, Controller, or persons performing similar functions.

A copy of the amended Code of Ethics is available on the Company's Internet website at www.hemispherx.net. A copy will be mailed to any person, without charge, upon written request addressed to:

Corporate Secretary
Hemispherx Biopharma, Inc.
1617 JFK Boulevard
Suite 660
Philadelphia, Pennsylvania, 19103