Item 5.02. Departure of Directors of Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

(d) On October 6, 2009, our Board of Directors appointed Thomas J. Lynch, Jr., M.D. as a director and to the Research and Development Committee of the Board. Dr. Lynch's term began on October 6, 2009 and will expire at our 2010 annual meeting of stockholders. In connection with his appointment to our Board, Dr. Lynch was granted an option to purchase up to 9,375 shares of our common stock at a price of $6.24 per share, which is equal to the closing price of our common stock on the Nasdaq Global Market on the date of grant. This option, which was granted under our 2000 Stock Incentive Plan, as amended, will vest and become exercisable in equal quarterly installments beginning at the end of the first quarter after the date of grant, provided that Dr. Lynch continues to serve as a director.

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