On September 10, 2009, Julius R. Krevans, M.D., Paul E. Freiman and John J. DiPietro resigned from the Board of Directors of Calypte Biomedical Corporation (the "Company") effective immediately. Dr. Krevans also resigned from the Audit Committee, the Compensation Committee, for which he was Chairman, and the Nominating Committee. Mr. Freiman also resigned from the Audit Committee, the Compensation Committee and the Nominating Committee. Mr. Freiman was Chairman of both the Audit Committee and the Nominating Committee. Mr. DiPietro also resigned from the Audit Committee. Dr. Krevans and Messrs. Freiman and DiPietro confirmed to the Board of Directors that their resignations were not the result of any disagreement on any matter relating to the Company's operations, policies or practices. The Company entered into a Resignation and Mutual Release with each of Dr. Krevans and Messrs. Freiman and DiPietro, pursuant to which the parties release each other from liability to the maximum extent allowed by law and the Company agrees to maintain certain levels of directors and officers liability insurance for a certain period of time. A copy of the form of the Resignation and Mutual Release is filed with this report as Exhibit 10.193.

ITEM 9.01                 Financial Statements and Exhibits

(d)      Exhibits.

Exhibit No.   Description

10.193        Form of Resignation and Mutual Release, dated
              September 10, 2009, between the Company and each
              of Dr. Krevans and Messrs. Freiman and DiPietro.