Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On September 14, 2009, The First Bancshares, Inc. issued a press release announcing that M. Ray "Hoppy" Cole will be named Chief Executive Officer (CEO) of The First, A National Banking Association and The First Bancshares, Inc, and will be taking over the day-to-day operations of the bank as of September 14, 2009. It was also announced that David E. Johnson will continue as Chairman of the Board of The First, A National Banking Association and The First Bancshares, Inc., carrying out newly-expanded responsibilities of that office.

M. Ray "Hoppy" Cole, Jr., is 47 years of age and has served as a Director since 1998 and has been employed by the bank since 2002, first as President of the Picayune, MS, location and then as Southern Region President. He became President of the banking system in 2006 and relocated his office to Hattiesburg, MS, in 2007.

The public announcement was made by means of a news release, the text of which is set forth in Exhibit 99.1 hereto.

Item 9.01. Financial Statements and Exhibits

(c) Exhibits
99.1 Press Release dated September 14, 2009

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