Item 1.01 Entry into a Material Definitive Agreement.

On September 11, 2009, the U.S. Air Force Research Laboratory awarded a fifteen-month, $1.5 million contract to CombiMatrix Corporation for the development of automated instrumentation that uses CombiMatrix's semiconductor microarray technologies for detecting chemical, biological and environmental hazards that can impact the health of deployed military personnel. Under the terms of this contract, CombiMatrix will perform research and development activities, as described under the contract, and will be reimbursed on a periodic basis for actual costs incurred to perform these obligations, plus a fixed fee, of up to $1.5 million.

Item 9.01. Financial Statements and Exhibits.

(d) Exhibits.

10.1 Research and development contract with the U.S. Air Force Research Laboratory for the Development and Use of a Semiconductor Microarray for Detecting Exposure to Environmental Hazards.

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