Item 1.01 Entry into a Material Definitive Agreement.

On August 19, 2009, ADVENTRX Pharmaceuticals, Inc. (the "Company") entered into a Second Amendment to Standard Multi-Tenant Office Lease - Gross, dated July 22, 2009, with Westcore Mesa View LLC and DD Mesa View LLC (the "Second Amendment"). The Second Amendment further amends that certain Stand Multi-Tenant Office Lease
- Gross, dated June 3, 2004, as amended by that certain First Amendment to Lease, dated May 12, 2005 (collectively, the "Original Lease") pursuant to which the Company leases offices at 6725 Mesa Ridge Road, San Diego, CA (the "Building"), which offices constitute its corporate headquarters.

Pursuant to the Original Lease, the Company leases approximately 8,865 rentable square feet commonly known as Suite 100 of the Building and 3,173 rentable square feet commonly known as Suite 102 of the Building (collectively, the "Premises"), which lease was to expire August 31, 2009. Pursuant to the Second Amendment, the Original Lease was amended to, among other things, reduce the Premises to approximately 3,173 rentable square feet consisting of solely the area previously referred to as Suite 102 of the Building (the "Reduced Premises") and extend the term of the Original Lease for an additional nine (9) months (i.e., from September 1, 2009 through May 31, 2010) (the "Extension Term"). The aggregate rent for the Reduced Premises for the Extension Term is approximately $33,000. The Company is also obligated to pay all other amounts due under the Original Lease.

The foregoing description of the terms of the Second Amendment is subject to, and qualified in its entirety by, the document attached hereto as Exhibit 10.1, which is incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

The list of exhibits called for by this Item is incorporated by reference to the Exhibit Index filed with this report.

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