On July 28, 2009, management of Prosperity Bancshares, Inc. (the "Company") presented information regarding the Company's business and second quarter 2009 operational results to investors at the Keefe, Bruyette & Woods 10th Annual Community Bank Conference in New York. The slide presentation given at this conference is furnished as Exhibit 99.1 to this Current Report on Form 8-K. The foregoing description is qualified by reference to such exhibit.

As provided in General Instruction B.2 to Form 8-K, the information in Item 7.01 and Exhibit 99.1 of this Current Report on Form 8-K is being furnished to the Securities and Exchange Commission and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, and such information shall not be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.

(d) Exhibits. The following is furnished as an exhibit to this Current Report on Form 8-K:

               Exhibit
               Number    Description of Exhibit
               99.1-     Investor presentation given July 28, 2009.