Submission of Matters to a Vote of Security Holders

On June 3, 2009, Helicos BioSciences Corporation ("Helicos" or the "Company") held its 2009 Annual Meeting of Stockholders. Out of 64,655,624 shares of common stock entitled to vote at the annual meeting, 61,774,921 shares were present in person or represented by proxy. The matters voted on and the results of the vote were as follows:

(a) Peter Barrett, PhD, Robert F. Higgins and Theo Melas-Kyriazi were elected to continue to serve as the Company's directors until the 2012 annual meeting of stockholders or until their successors are duly elected and qualified. The results of the vote were as follows:

                        For       Withheld
Peter Barrett, PhD   60,455,886   1,319,035
Robert F. Higgins    60,789,219     985,702
Theo Melas-Kyriazi   61,558,019     216,902

(b) The appointment of PricewaterhouseCoopers LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2009 was ratified. The results of the vote were as follows:

For Against Abstain Non-Votes 61,733,716 476 40,729 0

(c) The removal of certain share issuance limitations in warrants to purchase common stock issued in December 2008 was approved. The results of the vote were as follows:

For Against Abstain Non-Votes 57,725,664 56,227 27,265 3,965,765

(d) The amendment to the Company's Fourth Amended and Restated Certificate of Incorporation to effect a reverse stock split of the Company's outstanding common stock at an exchange ratio of (i) one-for-10, (ii) one-for-25 or (iii) any amount in between one-for-10 and one-for-25 and to authorize the Company's Board of Directors to implement the reverse stock split at any time prior to the 2010 annual meeting of stockholders was approved. The results of the vote were as follows:

For Against Abstain Non-Votes 61,178,089 575,748 21,084 0

(e) The amendment to the Company's Fourth Amended and Restated Certificate of Incorporation to increase the number of authorized shares of common stock from 120,000,000 to 200,000,000 and authorize the Company's Board of Directors to implement the increase in the number of authorized shares at any time prior to the 2010 annual meeting of stockholders if the reverse stock split is not implemented was approved. The results of the vote were as follows:

For Against Abstain Non-Votes 60,919,412 828,083 27,426 0