Item 8.01 Other Events.

On May 29, 2009, A.P. Pharma, Inc. (the "Company") announced that it has implemented a plan to reduce its work force by approximately 34%, or a total of 11 employees. The Company expects one-time costs associated with this headcount reduction to be approximately $350,000, which will be recorded in the second quarter of 2009. The actions are being taken to allow the Company to provide the resources needed to continue advancing its lead program, APF530, towards regulatory approval and commercialization.

Forward-Looking Statements

This current report contains forward-looking statements, including statements related to expected costs associated with the headcount reduction and the advancement of APF530 towards regulatory approval and commercialization. These forward-looking statements are based on the Company's current expectations and involve risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks related to difficulties or delays in seeking or obtaining regulatory approval and other risks details in the Company's filings with the Securities and Exchange Commission, including the Annual Report on Form 10-K for the year ended December 31, 2008 and periodic reports on Form 10-Q and Form 8-K. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this current report. All forward-looking statements are qualified in their entirety by this cautionary statement.