Item 2.02 Results of Operations and Financial Condition.

On May 7, 2009, Inspire Pharmaceuticals, Inc. issued a press release announcing its financial results for the first quarter ended March 31, 2009 and confirming the prior financial guidance for fiscal year 2009. The press release issued in connection with such announcement is attached hereto as Exhibit 99.1.

The information in this Current Report on Form 8-K, including the accompanying exhibit, is being furnished and shall not be deemed "filed" for purposes of
Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

No. Description
99.1 Press Release dated May 7, 2009

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