On May 6, 2009, OraSure Technologies, Inc. (the "Company") held a webcast conference call with analysts and investors, during which Douglas A. Michels, the Company's President and Chief Executive Officer, and Ronald H. Spair, the Company's Chief Financial Officer and Chief Operating Officer, discussed the Company's financial results for the quarter ended March 31, 2009, described certain business developments and provided financial guidance for the second quarter 2009. A copy of the prepared remarks of Messrs. Michels and Spair is attached as Exhibit 99 to this Form 8-K and is incorporated herein by reference.

(d) Exhibits

Exhibit
Number    Description
99        Prepared Remarks of Douglas A. Michels and Ronald H. Spair for OraSure
          Technologies, Inc. First Quarter 2009 Analyst/Investor Conference Call
          Held May 6, 2009.


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Signatures

Pursuant to the requirements of the Securities and Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.

Date: May 6, 2009 By: /s/ Jack E. Jerrett Jack E. Jerrett Senior Vice President, General Counsel and Secretary