Item 1.01 Entry into a Material Definitive Agreement.

On March 23, 2009 we amended our Collaborative Research, Development, Commercialization and License Agreement dated March 23, 2006 with Ajinomoto Co., Inc. to extend the collaborative period for an additional year, with three consecutive options of one year each that could further extend the collaboration. During the extension period, we will continue to work with Ajinomoto on the discovery, development and commercialization of new flavor ingredients for use in the soup, sauce and culinary aids, noodles and bouillon product categories in Asia. Under the terms of the extension, Ajinomoto has agreed to pay us incremental research funding. The potential milestone payments upon achievement of certain research and development goals remain unchanged. Upon commercialization, Ajinomoto will make royalty payments based on sales of Ajinomoto's products that contain Senomyx novel flavor ingredients discovered under the agreement.

We intend to file the agreement with the Securities and Exchange Commission in the future and will seek confidential treatment for certain material terms of the amendment at such time. The press release dated March 24, 2009 announcing our entry into the amendment and describing certain of its material terms is attached hereto as Exhibit 99.1 and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

99.1 Press release of Senomyx, Inc. dated March 24, 2009.

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