On February 11, 2009, OraSure Technologies, Inc. (the "Company") held a webcast conference call with analysts and investors, during which Douglas A. Michels, the Company's President and Chief Executive Officer, and Ronald H. Spair, the Company's Chief Financial Officer and Chief Operating Officer, discussed the Company's financial results for the quarter and full year ended December 31, 2008, described certain business developments and provided an update on financial guidance for the first quarter of 2009. A copy of the prepared remarks of Messrs. Michels and Spair is attached as Exhibit 99 to this Form 8-K and is incorporated herein by reference.

The information in this Current Report and attached Exhibit shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section, nor shall such information and Exhibit be deemed incorporated by reference in any filing under the Securities Act of 1933, except as shall be expressly set forth by specific reference in such a filing. The fact that the information and Exhibit are being furnished should not be deemed an admission as to the materiality of any information contained therein. The Company undertakes no duty or obligation to publicly update or revise the information contained in this Current Report or attached Exhibit.

(d) Exhibits

Exhibit Number           Description
99                       Prepared Remarks of Douglas A. Michels and Ronald H. Spair
                         for OraSure Technologies, Inc. Fourth Quarter and Full Year
                         2008 Analyst/Investor Conference Call Held February 11,
                         2009.