Item 7.01 Regulation FD Disclosure.

Helicos BioSciences Corporation (the "Company") is providing interim stockholder's equity and outstanding share information as of November 30, 2008, as set forth below for a resulting book value of $0.33 per share.

Book Value per Share = Stockholders' Equity / Total Shares Outstanding

$0.33 per share = $6,968,118 / 21,055,096 shares

In accordance with General Instruction B.2 of Form 8-K, the information in this Report shall not be deemed "filed" for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, except as shall be expressly set forth by specific reference in such a filing. The furnishing of the presentation materials is not intended to constitute a representation that such furnishing is required by Regulation FD or that the presentation materials include material investor information that is not otherwise publicly available.

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