Item 5.02 Departure of Directors or Principal Officers; Election of Directors;
Appointment of Principal Officers; Compensatory Arrangements of Certain Officers

(b) On December 2, 2008, Norman C. Payson, M.D. informed Idenix Pharmaceuticals, Inc. (the "Company") that he would resign as a member of the Board of Directors effective immediately. Dr. Payson's resignation was due to time constraints associated with his new position as Chairman and Chief Executive Officer of Apria Healthcare Group, Inc. following its acquisition by The Blackstone Group in October 2008 and was not caused by any disagreement with the Company on any matter related to the Company's operations, policies or practices.

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