Item 8.01 Other Events.

On November 6, 2008 we announced that we entered into a Collaborative Commercialization and License Agreement with Firmenich SA for S2383, our novel enhancer of the high-intensity sweetener sucralose. Under the terms of the agreement, Firmenich has agreed to pay to us royalty payments based on sales of S2383 when it is sold on either a stand-alone basis or within a flavor system.

The press release dated November 6, 2008 announcing our entry into the agreement and describing certain of its material terms is attached hereto as Exhibit 99.1 and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

99.1 Press release of Senomyx, Inc. dated November 6, 2008.

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