Item 1.01 Entry into a Material Definitive Agreement.

On October 31 2008, Martek Biosciences Corporation ("Martek") and Wyeth Nutritionals Ireland ("Wyeth Nutritionals"), a leading international producer of infant formula products, entered into a Supply Agreement (the "2008 Agreement"). The 2008 Agreement provides that Martek will serve as Wyeth Nutrionals' and its affiliates' worldwide sole source supplier of docosahexaeonic acid (DHA) and arachidonic acid (ARA) for all infant formula products. The 2008 Agreement has a ten-year term that runs until October 30, 2018. In addition to customary termination provisions with respect to breaches, insolvency and infringement of intellectual property rights, Wyeth Nutritionals may terminate the 2008 Agreement as of December 31, 2011, provided that Wyeth Nutritionals has given twelve months prior written notice.

Martek has been supplying DHA and ARA to Wyeth Nutritionals and its affiliates for use in infant formula products in connection with a 25-year license agreement signed in 1993 that remains in effect. The 1993 license agreement and exhibits are exhibits 10.07 and 10.07A to Martek's Form 10-K for the year ended October 31, 2007. The 2008 Agreement amends the 1993 license agreement and provides that, except under certain limited circumstances, no additional royalties will accrue under that license agreement as long as the 2008 Agreement is in effect.

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