On October 24, 2008, upon the recommendation of the Nominating and Corporate Governance Committee (the "Nominating Committee") of the Board of Directors (the "Board") of Senesco Technologies, Inc. ( the "Company"), the Board increased the size of the Board from eight (8) members to nine (9) members, and appointed Harlan Waksal M.D. to fill such vacancy. Dr. Waksal, 55, will serve until the Annual Meeting of Stockholders of the Company to be held in December 2008.

From July 2003 to present, Dr. Waksal has been the President and Sole Proprietor of Waksal Consulting L.L.C., which provides strategic business and clinical development counsel to biotechnology companies. Dr. Waksal co-founded the biotechnology company, ImClone Systems Inc., in 1984. From March 1987 through July 2003, Dr. Waksal had served in various senior roles for ImClone Systems Inc. as follows: March 1987 through April 1994 - President; April 1994 through May 2002 - Executive Vice President and Chief Operating Officer; May 2002 through July 2003 - President, Chief Executive Officer and Chief Operating Officer. Dr. Waksal also served as a director of ImClone Systems Inc. from March 1987 through January 2005. Dr. Waksal is the Chairman of the New Jersey Region of the American Committee for the Weizmann Institute of Science, and he is also a member of the Boards of Trustees of The Montclair Art Museum, Oberlin College and the American Committee for the Weizmann Institute of Science. Dr. Waksal received a Bachelor of Arts in Biology from Oberlin College and an M.D. from Tufts University School of Medicine.

The Board determined that Dr. Waksal has no relationship with the Company or its subsidiaries, either directly or indirectly, that would be inconsistent with a determination of independence under the applicable rules and regulations of the NYSE Alternext or the Securities and Exchange Commission.

The Board is in the process of determining which committees Dr. Waksal shall serve upon, if any.

Dr. Waksal will receive compensation consistent with that awarded, as previously disclosed in the Company's proxy statement, to other Board members for his duties performed in serving on the Board.

Neither Dr. Waksal nor any member of his immediate family has engaged, directly or indirectly, in any transaction, or series of similar transactions, with the Company or any of its subsidiaries since June 30, 2008 in which the amount involved exceeds $120,000. In addition, Dr. Waksal does not have any family relationship with any executive officer or director of the Company.

On October 29,2008, the Company issued a press release announcing the appointment of Dr. Waksal to serve as director of the Company. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K.

(d) Exhibits

Exhibit No.                                Description

   99.1        Press Release issued by Senesco Technologies, Inc. on October 29,
               2008 announcing the appointment of Dr. Waksal to serve as a director
               of the Company.