Item 8.01 Other Events

As previously disclosed, Manhattan Pharmaceuticals, Inc. (the "Company") has been involved in an arbitration proceeding in Switzerland with Swiss Pharma Contract LTD ("Swiss Pharma"), a clinical site that the Company used in one of its obesity trials. On September 5, 2008, the sole arbitrator in Switzerland rendered an award in favor of Swiss Pharma, awarding to Swiss Pharma a total of $646,000 which amount includes a $323,000 contract penalty, a final services invoice of $48,000, reimbursement of certain of Swiss Pharma's legal and other expenses incurred in the arbitration process of $245,000, reimbursement of arbitration costs of $13,000 and interest through September 5, 2008 of $17,000. Further, the arbitrator ruled that the Company must pay interest at the rate of 5% per annum on $371,000, the sum of the $323,000 contract penalty and the final services invoice of $48,000, from October 12, 2007 until paid.

The Company has previously recognized a liability to Swiss Pharma in the amount of $104,000 for the final services invoice. Therefore the Company will recognize expense for the difference between the award of $646,000 and the previously recognized liability of $104,000, or $542,000, in the quarter ending September 30, 2008. The Company will also continue to accrue interest at the rate of 5% per annum on the $371,000.

The Company disagrees with the result of the arbitration and is exploring its post-award options, including potential appellate remedies in Switzerland, and defense of any actions which may be taken to enforce the arbitration award.

The Company does not have sufficient cash or other current assets to satisfy the arbitrator's award.

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