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| CORT > SEC Filings for CORT > Form 8-K on 5-Sep-2008 | All Recent SEC Filings |
5-Sep-2008
Regulation FD Disclosure
The information in this Item 7.01 of this Current Report on Form 8-K, including
the exhibits attached hereto, is furnished pursuant to Item 7.01 and shall not
be deemed "filed" for any purpose, including for the purposes of Section 18 of
the Exchange Act, or otherwise subject to the liabilities of that Section. The
information in this Item 7.01 of this Current Report on Form 8-K, including the
exhibits attached hereto, shall not be deemed incorporated by reference into any
filing under the Securities Act or the Exchange Act regardless of any general
incorporation language in such filing.
On September 3, 2008, the Company issued the press release attached hereto as
Exhibit 99.1. The text of the press release is incorporated by reference herein.
Item 8.01. Other Events
On September 2, 2008 Corcept entered into an agreement with Eli Lilly and
Company (Lilly) whereby Lilly agreed to fund studies by the Company to test the
effectiveness of Corcept's selective GRII receptor antagonist, CORT 108297, in
rat models of olanzapine induced weight gain.
Corcept has previously published the results of studies in rats that
demonstrated that CORLUX, a potent GRII (cortisol) receptor antagonist, both
reduced the weight gain associated with the ongoing use of olanzapine and
mitigated the weight gain associated with the initiation of treatment with
olanzapine. In August of 2007, Corcept also announced that the results of a
clinical trial in healthy men indicated that CORLUX mitigated the weight gain
associated with the initiation of treatment with olanzapine. Lilly supplied
olanzapine and provided the funds for this human proof of concept study.
In addition to blocking the GRII (cortisol) receptor, CORLUX is a potent blocker
of the PR (progesterone) receptor. CORT 108297 blocks the GRII receptor but does
not have affinity for the PR receptor.
Item 9.01. Financial Statements and Exhibits
(a) Financial statements:
None
(b) Pro forma financial information:
None
(c) Shell company transactions:
None
(d) Exhibits
99.1 Press Release of Corcept Therapeutics Incorporated dated September 03, 2008
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