(e) On July 22, 2008, at the annual meeting of stockholders of Synvista Therapeutics, Inc. (the "Company"), stockholders of the Company approved an amendment to the Synvista 2005 Stock Plan (the "Plan"), that increased the number of shares of common stock reserved for issuance under the Plan from 1,060,000 shares to 2,000,000 shares.

(a) On July 22, 2008, at the annual meeting of stockholders of the Company, stockholders of the Company approved an amendment to the Company's Restated Certificate of Incorporation to decrease the number of shares of common stock authorized for issuance from 300,000,000 to 150,000,000. A copy of the Certificate of Amendment of Restated Certificate of Incorporation is attached hereto as Exhibit 3.1 and incorporated herein by reference.

(b) Not applicable.

(d) Exhibits.

Exhibit                    Description
Number

3.1      Certificate of Amendment of Restated Certificate
         of Incorporation of Synvista Therapeutics, Inc.
         dated July 22, 2008.